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Photo Caption: The pathogenic bacterium Pseudomonas aeruginosa breaching through the respiratory epithelia of a human lung microtissue model, captured via Scanning Electron Microscopy. Credit: Benoit Laventie, Biozentrum, University of Basel

How can pathogens enter the lungs? A team at the University of Basel’s Biozentrum discovered a deadly pathogen’s approach by studying human lung microtissues. The bacterium targets specific lung cells and has devised a complex technique to overcome the lungs’ defenses.

Earlier in 2024, the World Health Organization published a list of 12 of the world’s most deadly bacterial infections, which are resistant to various antibiotics and pose a serious threat to human health. This list includes Pseudomonas aeruginosa, a highly feared nosocomial infection that causes severe and fatal pneumonia. This pathogen is particularly dangerous to immunocompromised individuals and those requiring mechanical ventilation, with fatality rates of up to 50%.

https://phys.org/news/2024-06-lung-organoids-reveal-pathogens-infect.html

https://www.nature.com/articles/s41564-024-01718-6

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