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Original Source: https://doi.org/10.1016/j.cell.2020.08.048

• The primary function of the colon is to absorb fluids.

• The colon contains a large number of microorganisms including fungi, which are elevated near the end of the segment.

• The mucous membrane of the colon must regulate fluid influx to control absorption of metabolites from fungi.

• Fungal metabolites can be toxic to epithelial cells and lead to barrier dysfunction.

• The mechanism of the fluid influx regulation is still unclear.

• The study describe a mechanism by which the immune system is associated with quality checking the fluid absorption to avoid intoxication of epithelial cells of the colon.

• The mechanism relies on a number of distal colon macrophages attached to the epithelium.

• If the macrophages are not present, epithelial cells keep absorbing fluids containing fungal products.

• When epithelial cells absorb fungal products, they die and the epithelial barrier losses integrity.

• The data reveal an essential role of macrophages in the maintenance of colon-microbiota interactions in homeostasis.

Source:

https://doi.org/10.1016/j.cell.2020.08.048

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Keywords: how fluids in colon are filtered, what cleans fluid in colon, colon fluid filtration, colon fluid absorption regulation, regulation of fluid in colon, role of macrophages in colon