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• Fecal microbiota transplantation is when stool from a healthy donor is transferred into the colon of a sick person to introduce good bacteria.

• Fecal microbiota transplantation is effective for recurrent Clostridioides difficile infection.

• However, inconsistent effect rates and uncertain evidence levels have caused concerns.

• Clostridioides difficile infection occurs when an opportunistic bacteria infects the colon usually after taking antibiotics.

• Researchers aimed to establish the evidence of fecal microbiota transplantation for recurrent Clostridioides difficile infection.

• The clinical effect of a single fecal microbiota transplantation was 84 percent.

• The clinical effect of a repeat fecal microbiota transplantation was 91 percent.

• Fecal microbiota transplantation delivered by lower gastrointestinal endoscopy was the most effective of all delivery methods.

• Repeat fecal microbiota transplantation significantly increased the treatment effect.

• Data shows that the number of patients to be treated decreased after repeat fecal microbiota transplantation.

• Evidence supports fecal microbiota transplantation is effective in treating recurrent Clostridioides difficile infection however, its effect varies with the delivery method and the number of administration.

• The findings suggest that patients may benefit from advancing fecal microbiota transplantation to all cases of recurrent Clostridioides difficile infection.

Sources:

https://doi.org/10.1016/j.eclinm.2020.100642

https://gastro.org/practice-guidance/gi-patient-center/topic/fecal-microbiota-transplantation-fmt

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