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• The COVID-19 virus has quickly spread within the human population.

• The COVID-19 virus is a new type of coronavirus.

• However, humans had been previously exposed to common seasonal human coronavirus before the COVID-19 pandemic.

• Common human coronaviruses usually cause mild/moderate upper-respiratory tract diseases such as the common cold.[1]

• Researchers quantified levels of antibodies induced by COVID-19 virus and antibodies induced by the common seasonal human coronavirus.

• Samples were collected from 431 individuals before the COVID-19 pandemic.

• Researchers then quantified pre-pandemic antibody levels from another group of 251 individuals who became infected with the COVID-19 virus.

• Finally, both COVID-19 and common seasonal human coronavirus antibodies were measure in hospitalized COVID-19 patients.

• Data show that most individuals possessed common seasonal human coronavirus antibodies before the COVID-19 pandemic.

• Researchers determined that about 20 percent of these individuals possessed non-neutralizing antibodies that cross-reacted with the COVID-19 virus spike and proteins.

• The non-neutralizing antibodies do not seem to protect individual against the COVID-19 virus.

• The non-neutralizing antibodies were boosted upon COVID-19 viral infection.

Sources:

https://doi.org/10.1016/j.cell.2021.02.010

[1] https://www.cdc.gov/coronavirus/general-information.html

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