The Chromoscience

COVID-19 in Pregnancy Linked To Maternal Morbidity/Mortality and Newborn Complications

Benison P. Zerrudo
1–2 minutes

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Image Source: https://www.cdc.gov/mmwr/volumes/69/wr/mm6938e1.htm

  • Information about the association of COVID-19 with the outcomes in pregnant individuals compared with non-infected pregnant individuals is importantly needed.
  • Researchers evaluated the risks associated with COVID-19 in pregnancy on maternal and newborn outcomes.
  • Research study timeline: March to October 2020.
  • The study involved 43 institutions in 18 countries.
  • Every woman identified as infected, non-infected women were simultaneously enrolled immediately.
  • The women can be at any stage of pregnancy or delivery and had the same level of care to reduce bias.
  • The women and newborn individuals were followed up until discharge from the hospital.
  • Researchers determined morbidity and mortality as the primary outcome measures.
  • Total number of pregnant women with COVID-19: 706
  • Total number of pregnant women without COVID-19: 1424
  • Mean age: 30.2
  • 48.6% of women with COVID-19 became overweight early in pregnancy while 40.2% without COVID-19.
  • Women with COVID-19 were at higher risk for preeclampsia/eclampsia, severe infections, intensive care unit admission, maternal mortality, preterm birth, medically indicated-preterm birth, severe neonatal morbidity index, and severe perinatal morbidity and mortality index.
  • Shortness of breath and fever was associated with an increased risk of severe maternal complications and neonatal complications.
  • Asymptomatic COVID-19 women remained at higher risk only for maternal morbidity and preeclampsia.
  • For women who tested positive, 13% of their newborns tested positive.
  • Cesarean delivery, not breastfeeding, is likely to cause positive COVID-19 test results in newborn babies.
  • The results revealed that COVID-19 in pregnancy was linked with increases in severe maternal morbidity and mortality and newborn complications when COVID-19 and non-COVID-19 pregnant women were compared.
  • These findings should create awareness in pregnant women and clinicians to implement recommended COVID-19 preventive procedures.

Source:

Villar, J., Ariff, S., Gunier, R. B., Thiruvengadam, R., Rauch, S., Kholin, A., Roggero, P., Prefumo, F., do Vale, M. S., Cardona-Perez, J. A., Maiz, N., Cetin, I., Savasi, V., Deruelle, P., Easter, S. R., Sichitiu, J., Soto Conti, C. P., Ernawati, E., Mhatre, M., Teji, J. S., … Papageorghiou, A. T. (2021). Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study. JAMA pediatrics, 10.1001/jamapediatrics.2021.1050. Advance online publication. https://doi.org/10.1001/jamapediatrics.2021.1050

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The Chromoscience uses AI-assisted tools to support the preparation and editing of science articles. Content is reviewed by the editor for clarity and consistency with the cited research before publication. Readers are encouraged to consult the original scientific publications for complete findings, methods, and limitations.

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